Low Dose Naltrexone
There are a number of proven solutions for reducing inflammation. One such option is low dose naltrexone — commonly called LDN — which refers to naltrexone taken at a fraction of the standard dose: typically 1.5 mg to 4.5 mg per day, compared to the commercially available 50 mg tablet used for addiction medicine.
At this lower dose, naltrexone works through an entirely different mechanism — one that researchers believe may gently modulate the immune system and support the body's natural anti-inflammatory pathways.
Because the 50 mg commercial dose cannot be divided safely or accurately to these levels, LDN is only available through a compounding pharmacy. There is no FDA-approved LDN product — every prescription must be individually prepared.
Conditions
LDN has received growing attention in the clinical research community as an adjunct therapy for conditions driven by immune dysregulation. Patients and prescribers have explored LDN in:
LDN's proposed anti-inflammatory and glial-modulating effects have made it a subject of interest for patients with conditions involving central sensitization and persistent pain, including:
Early-stage research is also exploring LDN's potential role in mood regulation and neurological conditions, including:
LDN is almost always started at a low dose — often as low as 0.5 mg to 1.5 mg — and gradually titrated upward over weeks. This approach helps minimize initial side effects (most commonly, vivid dreams or mild sleep disturbance in the early weeks) and allows the prescribing clinician to find the therapeutic level that works best for each individual.
Because titration is essential to success, compounding pharmacies are uniquely suited to support LDN therapy: we can prepare capsules at any specific strength your prescriber designates throughout the titration process.
Our compounded LDN formulations give prescribers the flexibility to meet diverse patient needs. Every strength is prepared fresh at our Baltimore pharmacy under USP-compliant standards, with pharmacist support available for prescriber questions on dosing and titration.
capsules compounded at exact prescribed strengths from 0.1 mg to 4.5 mg
0.1 mg, 0.5 mg, 1.5 mg, 2 mg, 3 mg, and 4.5 mg — the full therapeutic range
customized ultra-low starting doses for sensitive patients or complex titration plans
30-, 60-, and 90-count quantities to support ongoing treatment plans
Compounding
At Voshell's Pharmacy, LDN is most commonly prepared as:
We prepare each batch with careful attention to uniformity and dose accuracy — because with LDN, the dose is the therapy.
#LDN may be appropriate for your condition
LDN is prescribed off-label for most of the conditions listed above. Compounded LDN is not FDA-approved. Clinical evidence varies by condition and is ongoing. All LDN therapy requires a valid prescription from a licensed prescriber. Compounded medications may not be appropriate for all patients.
